This review provides a comprehensive overview of current microenvironment-targeted strategies and challenges for bone regeneration and further outlines prospective directions of the approaches in construction of bone organoids. Microenvironment-targeted strategies are increasingly recognized as crucial for successful bone regeneration and offer promising solutions for advancing bone tissue engineering. The bone microenvironment is a sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical (e.g., oxygen, pH), and physical factors (e.g., mechanics, acoustics) that dynamically interact with each other. However, the synergistic effects of other cues from the microenvironment during bone regeneration are often neglected. Traditional strategies in bone tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) of bone in terms of structure and composition.
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With no mineral isolates, synthetics or limestone, Bone Renewal® is pure, plant-based and bioavailable. Because calcium alone is not enough, our groundbreaking three-part formula features plant-based nutrients, trace minerals, and bone-nourishing botanical extracts.
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